Stem cell therapy has emerged as a promising alternative for people suffering from chronic knee pain due to osteoarthritis, injury, or degeneration. As patients seek less invasive treatments with quicker recovery times, stem cell therapy offers hope by promoting tissue regeneration, reducing inflammation, and potentially delaying or avoiding knee replacement surgery.
In this comprehensive 2025 guide, we explore the best types of stem cell therapy for knee pain, associated costs, leading clinics, and key factors to consider — including a helpful FAQ section at the end.
What Is Stem Cell Therapy for Knee Pain?
Stem cell therapy involves injecting concentrated stem cells into the affected knee joint to aid in repairing damaged cartilage, reduce inflammation, and improve function. The most commonly used stem cells in knee therapy are:
- Mesenchymal Stem Cells (MSCs): Derived from bone marrow or adipose (fat) tissue
- Amniotic Stem Cells: Sourced from donated amniotic fluid (less commonly used)
- Umbilical Cord-Derived Cells: Collected after childbirth with consent
Types of Stem Cell Therapy for Knee Pain
- Bone Marrow-Derived MSCs (BMAC)
- Harvested from the patient’s hip bone
- Contains growth factors and anti-inflammatory cytokines
- Ideal for osteoarthritis and cartilage repair
- Adipose-Derived Stem Cells (ADSCs)
- Extracted from fat tissue via liposuction
- High stem cell yield and good anti-inflammatory response
- Umbilical Cord Stem Cells (Allogeneic)
- Donor-derived, processed in FDA-regulated labs
- Useful for patients unable to use their own cells
- Platelet-Rich Plasma (PRP) + Stem Cells
- Combines stem cells with platelets to amplify healing
- Often used as a regenerative medicine protocol
Average Cost of Stem Cell Therapy for Knee Pain in 2025
The cost of stem cell treatment for knee pain varies widely depending on the type of procedure, provider, and location.
| Type of Therapy | Cost Range (USD) |
|---|---|
| Bone Marrow (BMAC) | $3,500 – $8,000 |
| Adipose-Derived Cells | $4,000 – $7,000 |
| Umbilical Cord Cells | $5,000 – $10,000 |
| PRP + Stem Cells | $2,500 – $6,000 |
Note: These treatments are usually not covered by insurance as they are considered elective or experimental by most providers.
Top Clinics Offering Stem Cell Therapy for Knee Pain
- Regenexx
- Pioneer in orthopedic stem cell therapies
- Extensive network in the U.S. and abroad
- Visit Regenexx
- Celltex Therapeutics (Houston, TX)
- Specializes in expanded MSC therapy
- FDA-registered lab with international partnerships
- Visit Celltex
- The Stem Cell Institute (Panama)
- International leader in stem cell therapy
- Treats orthopedic and autoimmune conditions
- Visit Stem Cell Institute
- GIOSTAR (Global Institute of Stem Cell Therapy and Research)
- Offers therapies in the U.S., Mexico, and India
- Focuses on regenerative orthopedics
- Visit GIOSTAR
- DOC (Disc of Columbia) – California & Florida
- Regenerative medicine and orthopedic pain specialists
- Combines PRP and stem cells
- Visit DOC
Benefits of Stem Cell Therapy for Knee Pain
- Minimally invasive (no major surgery required)
- Reduced recovery time vs knee replacement
- Lower risk of complications
- Potential for cartilage regeneration
- Improved knee function and mobility
Risks and Considerations
- Not all patients are good candidates (severe degeneration may limit effectiveness)
- Not FDA-approved as a cure — considered experimental in the U.S.
- Results may vary; not guaranteed
- Potential risks: infection, swelling, no improvement
What to Look for in a Stem Cell Therapy Clinic
- Licensed and board-certified physicians
- Use of FDA-compliant labs and protocols
- Transparent pricing and treatment plans
- Patient reviews and outcome data
- Follow-up and rehab guidance
FAQs: Stem Cell Therapy for Knee Pain
Q1: Is stem cell therapy FDA-approved for knee pain?
A: While some labs and procedures are FDA-compliant, most stem cell treatments are considered investigational and not officially FDA-approved.
Q2: How long does it take to see results?
A: Most patients report improvements within 2–3 months, with continued gains for up to 6 months.
Q3: Are the results permanent?
A: Some patients experience long-term relief for years, while others may need repeat treatments every 1–2 years.
Q4: Will insurance cover it?
A: Generally no — most insurers classify it as elective or experimental.
Q5: Can stem cells regenerate cartilage?
A: Evidence suggests potential for regeneration, especially in early-stage osteoarthritis, but results are not guaranteed.
Q6: Who should not get stem cell therapy?
A: Patients with cancer, active infections, or advanced joint degeneration may not be ideal candidates.
Final Thoughts
Stem cell therapy offers a promising path for managing knee pain without surgery — especially for those in early-to-mid stages of arthritis or post-injury. While costs can be high and results vary, it remains a popular choice among those seeking cutting-edge, regenerative alternatives to invasive orthopedic procedures.
Always consult with a licensed orthopedic or regenerative medicine specialist to determine your suitability for treatment.
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